Yuko and Eri are two normal girls who are sucked into the alternate world filled with tiny people. The people of this mysterious world sees them as their "Great Protectors" who can protect their land in a time of strife. The two girls set out on a mission with a group of warriors from the village to find out how they were brought here and how might they return home. However, there is a war brewing and these two Great Protectors are the political tool that every faction lusts for to rally the people to their side.
It is the Correct Century, two millenniums after a devastating conflict which left the world broken. Earth is now mostly uninhabitable, and thus a remnant of humanity has resided on the Moon while the Earth and its few survivors recover.
In a future, decimated Earth after the discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth. The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.
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