In the year 2024, the world has collapsed. Grotesque monsters lurk amongst the ruins of Japan, while remaining people scrape together what they can to survive. Kiruko, an odd-job girl in Nakano, accepts a mysterious woman's dying wish to take a boy named Maru to a place called Heaven. Maru is convinced that there will be a boy there who looks exactly like him.
Shōtarō Tatewaki is a normal high school student with a serious demeanor hangs around with Sakurako Kujō. Sakurako is an extraordinarily beautiful woman in her mid-20s from a rich family who loves "beautiful bones." The two live in the city of Asahikawa in Hokkaido, and they get involved in various incidents regarding bones.
In 2710, a boy named Shinichi is on a school field trip to a rebuilt 21st century version of the city Nara. When he wanders from his class, he spots a talking white deer and it steals his bag. Shinichi follows the deer and sees a strange girl named Toto and falls in love with her. She is being pursed by two brothers and they try to get away from them.
The story is set in a village in the southern Japanese prefecture of Kōchi during World War II. Even in this remote mountainous area, the perception of American and British people as "brutes" has taken root, due to the deaths and injuries among the villagers' relatives. A elementary schoolgirl named Eiko transfers from the city of Yokohama to this village. Eiko happens to have blue eyes from her American father, and her classmates make no attempt to rein in their bullying. Other than Eiko's homeroom teacher Akiko, even the teachers view Eiko the same way that the children do. However, a boy named Kenta views Eiko more with curiosity than with hostility. The children's lives change as the injured father of one of Kenta's classmates returns from the battlefield and news of more casualties arrives in the village.
Three young girls, strangers to each other, share an instinctual passion and talent for music. Brought together from distinctly different worlds, they meet by chance at the concert of their idol. The concert strikes a chord in each of their hearts and unites them with a common dream of stardom. The girls each enroll in the same music school and are brought together again in a special class for exceptional talent. As their voices come together in harmony, the girls realize that they share more than just a passion for song. A mysterious blue stone, a hauntingly beautiful meoldy... what do these traces of the past have to do with the uncertain future of this gifted trio?
In a future, decimated Earth after the discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth. The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.
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