Robert Castle is the idealistic pastor of St. Mary's Episcopal Church in Harlem, and also the cousin of filmmaker Jonathan Demme. Demme's affectionate portrait of his cousin traces Castle's story, beginning with his first parish assignment, in New Jersey in the early 1960s, in an increasingly African-American-populated neighborhood rocked by violence and civil rights protests. The film raises intimate discussions of race, faith and family, while also showing Castle's daily routine as a pastor.
Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.
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